Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Homocysteine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | GSR | P00390 | 2/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homocysteine SCHEMBL7785059 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11PMP22GSRGRM8 | |
| L-Homocysteine SCHEMBL7785056 | 1.00 | PTGS1 (0.52) | PTGS1SLC7A11PMP22GSRGRM8 | |
| Homocysteine SCHEMBL27563537 | 0.91 | PTGS1 (0.52) | PTGS1SLC7A11PMP22GSRGRM8 | |
| Homocysteine SCHEMBL936365 | 0.91 | PTGS1 (0.62) | PTGS1SLC7A11PMP22GSRGRM8 | |
| Homocysteine SCHEMBL601148 | 0.91 | — | — | |
| Homocysteine SCHEMBL28927454 | 0.91 | PTGS1 (0.62) | PTGS1SLC7A11PMP22GSRGRM8 | |
| L-Homocysteine SCHEMBL35837 | 0.91 | — | — | |
| Homocysteine SCHEMBL35836 | 0.91 | — | — | |
| L-Homocysteine SCHEMBL936366 | 0.91 | PTGS1 (0.62) | PTGS1SLC7A11PMP22GSRGRM8 | |
| Homocysteine SCHEMBL27589396 | 0.90 | PTGS1 (0.46) | PTGS1SLC7A11PMP22GSRGRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077971-A | TREATING CRUDE HOMOCYSTINE CONTAINING A POLYSULFIDE WITH A BASE SELECTED FROM AN AQUEOUS SOLUTION OF AN ALKALI METAL HYDROXIDE, AMMONIA, OR AMINE. | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-06-20 | — | — | US | claimed |
| EP-0921118-A1 | Method for purifying homocystine | Mitsubishi Chemical Corporation (JP) | 1999-06-09 | — | — | EP | claimed |
| CN-119181506-B | Recognition model construction system, storage medium and kit for cardiovascular metabolism risk factor spectrum | 上海交通大学医学院附属仁济医院 | 2025-03-18 | — | — | CN | disclosed |
| CN-119584951-A | Composition comprising a UV filter stabilizer | 西姆莱斯股份公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119181506-A | Recognition model construction system, storage medium and kit for cardiovascular metabolism risk factor spectrum | 上海交通大学医学院附属仁济医院 | 2024-12-24 | — | — | CN | disclosed |
| EP-0844239-B1 | Method for producing homocystine | MITSUBISHI CHEM CORP (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-6077971-A | TREATING CRUDE HOMOCYSTINE CONTAINING A POLYSULFIDE WITH A BASE SELECTED FROM AN AQUEOUS SOLUTION OF AN ALKALI METAL HYDROXIDE, AMMONIA, OR AMINE. | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-06-20 | — | — | US | disclosed |
| EP-0921118-A1 | Method for purifying homocystine | Mitsubishi Chemical Corporation (JP) | 1999-06-09 | — | — | EP | disclosed |
| US-5847205-A | Method for producing homocystine | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0844239-A1 | Method for producing homocystine | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-27 | — | — | EP | disclosed |