Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11808670 | 0.89 | POLB (0.68) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL668906 | 0.89 | POLB (0.68) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL1919158 | 0.87 | POLB (0.66) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL20677078 | 0.83 | POLB (0.61) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL18855421 | 0.81 | POLB (0.63) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL12162974 | 0.80 | RAB9A (0.44) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL7793309 | 0.80 | POLB (0.58) | POLBRHOCRHOAJAK2FPR2 | |
| SCHEMBL13450330 | 0.80 | POLB (0.62) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL15476132 | 0.80 | EPHX2 (0.41) | POLBSMN1; SMN2RAB9ANPC1EPHX1 | |
| SCHEMBL7793331 | 0.80 | RAB9A (0.44) | POLBSMN1; SMN2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |