Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784699 | 1.00 | NAMPT (0.52) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7786748 | 0.99 | NAMPT (0.51) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7786749 | 0.99 | NAMPT (0.51) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| SCHEMBL7784237 | 0.81 | MC4R (0.55) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| SCHEMBL8477270 | 0.81 | MC4R (0.55) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7786422 | 0.80 | MC4R (0.53) | NAMPTSMN1; SMN2GAAALDH1A1LMNA | |
| SCHEMBL7787741 | 0.79 | MC4R (0.52) | GAAALDH1A1POLBKMT2A | |
| SCHEMBL7787742 | 0.79 | MC4R (0.52) | GAAALDH1A1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL7787633 | 0.78 | MC4R (0.51) | GAAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4773141 | 0.78 | FFAR1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |