Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787742 | 1.00 | MC4R (0.52) | MC4RTAAR1POLBGAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7787633 | 0.99 | MC4R (0.51) | MC4RTAAR1POLBGAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL7787634 | 0.99 | MC4R (0.51) | MC4RTAAR1POLBGAASIGMAR1 | |
| SCHEMBL7779656 | 0.93 | KMT2A (0.48) | MC4RTAAR1POLBGAASIGMAR1 | |
| SCHEMBL7786460 | 0.93 | KMT2A (0.48) | MC4RTAAR1POLBGAASIGMAR1 | |
| SCHEMBL7779659 | 0.93 | KMT2A (0.48) | MC4RTAAR1POLBGAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL8477512 | 0.92 | KMT2A (0.47) | MC4RTAAR1POLBGAASIGMAR1 | |
| SCHEMBL8477270 | 0.88 | MC4R (0.55) | MC4RPOLBGAASIGMAR1TLR2 | |
| SCHEMBL7784237 | 0.88 | MC4R (0.55) | MC4RPOLBGAASIGMAR1TLR2 | |
| Hydrochloric Acid SCHEMBL7786422 | 0.87 | MC4R (0.53) | MC4RPOLBGAASIGMAR1TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |