Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.37 |
| ▸ | DRD4 | P21917 | 8/20 | 0.37 |
| ▸ | DRD3 | P35462 | 8/20 | 0.37 |
| ▸ | XIAP | P98170 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 2/20 | 0.35 |
| ▸ | F3 | P13726 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791742 | 0.94 | GHSR (0.54) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7791835 | 0.94 | GHSR (0.53) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7785745 | 0.93 | GHSR (0.52) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7794624 | 0.91 | GHSR (0.45) | GHSRXIAPHTR7F7F3 | |
| SCHEMBL8330639 | 0.91 | GHSR (0.57) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7786009 | 0.90 | GHSR (0.54) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7785733 | 0.90 | GHSR (0.60) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7791716 | 0.90 | GHSR (0.66) | GHSRDRD2DRD4DRD3XIAP | |
| SCHEMBL7791676 | 0.89 | GHSR (0.54) | GHSRXIAPF7F3MAPT | |
| SCHEMBL7791541 | 0.89 | GHSR (0.53) | GHSRDRD2DRD4DRD3XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | claimed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |