Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794793 | 0.97 | HTR2C (0.46) | HTR2CHTR2BCYP2D6TSHRKDM4E | |
| SCHEMBL7795930 | 0.95 | KDM4E (0.46) | HTR2CHTR2BKDM4EALDH1A1HTT | |
| SCHEMBL7794702 | 0.95 | KDM4E (0.46) | HTR2CHTR2BKDM4EALDH1A1HTT | |
| SCHEMBL7796105 | 0.93 | HTR2C (0.48) | HTR2CHTR2BCYP2D6TSHRKDM4E | |
| SCHEMBL7786497 | 0.93 | KDM4E (0.44) | HTR2CHTR2BTSHRKDM4EALDH1A1 | |
| SCHEMBL7792051 | 0.93 | KDM4E (0.44) | HTR2CHTR2BTSHRKDM4EALDH1A1 | |
| SCHEMBL27513181 | 0.92 | HTR2C (0.42) | HTR2CHTR2BCYP2D6TSHRKDM4E | |
| SCHEMBL27513180 | 0.92 | HTR2C (0.41) | HTR2CHTR2BCYP2D6TSHRKDM4E | |
| SCHEMBL7786092 | 0.92 | HTR2C (0.46) | HTR2CHTR2BCYP2D6TSHRKDM4E | |
| SCHEMBL7796495 | 0.91 | POLB (0.48) | HTR2CHTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |