Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794702 | 1.00 | KDM4E (0.46) | KDM4EHTTALDH1A1MEN1USP2 | |
| SCHEMBL7792051 | 0.97 | KDM4E (0.44) | KDM4EHTTALDH1A1MEN1USP2 | |
| SCHEMBL7786497 | 0.97 | KDM4E (0.44) | KDM4EHTTALDH1A1MEN1USP2 | |
| SCHEMBL7794793 | 0.96 | HTR2C (0.46) | KDM4EHTTALDH1A1MEN1USP2 | |
| SCHEMBL7786149 | 0.95 | HTR2C (0.47) | KDM4EHTTALDH1A1MEN1USP2 | |
| SCHEMBL7794711 | 0.95 | KDM4E (0.47) | KDM4EHTTALDH1A1USP2FLT3 | |
| SCHEMBL7786118 | 0.94 | KDM4E (0.46) | KDM4EKMT2ABRD4ADORA2AADORA1 | |
| SCHEMBL7792297 | 0.94 | KDM4E (0.46) | KDM4EKMT2ABRD4ADORA2AADORA1 | |
| SCHEMBL7792725 | 0.93 | KDM4E (0.45) | KDM4EALDH1A1USP2BRD4ADORA2A | |
| SCHEMBL7796105 | 0.92 | HTR2C (0.48) | KDM4EALDH1A1BRD4ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |