Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794758 | 0.99 | HRH3 (0.56) | HRH3KCNH2MAOAMAOBALDH1A1 | |
| SCHEMBL7796613 | 0.96 | HRH3 (0.52) | HRH3KCNH2MAOAMAOBALDH1A1 | |
| SCHEMBL7786095 | 0.95 | HRH3 (0.54) | HRH3KCNH2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7794688 | 0.94 | POLB (0.53) | HRH3KCNH2MAOB | |
| SCHEMBL27493228 | 0.94 | HRH3 (0.50) | HRH3KCNH2MAOAMAOBALDH1A1 | |
| SCHEMBL7792055 | 0.94 | POLB (0.52) | HRH3KCNH2MAOB | |
| SCHEMBL27513182 | 0.93 | HRH3 (0.52) | HRH3KCNH2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7786234 | 0.91 | MET (0.50) | HRH3KCNH2ALDH1A1CYP2D6KDM4E | |
| SCHEMBL7786388 | 0.91 | MET (0.50) | HRH3KCNH2ALDH1A1CYP2D6KDM4E | |
| SCHEMBL7792451 | 0.91 | HRH3 (0.49) | HRH3KCNH2MAOBALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |