Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786169 | 0.99 | HRH3 (0.58) | HRH3ADORA2AADORA1HTR3EHTR3B | |
| SCHEMBL7794749 | 0.94 | HRH3 (0.57) | HRH3ADORA2AADORA1 | |
| SCHEMBL7792591 | 0.93 | HRH3 (0.59) | HRH3ADORA2AADORA1 | |
| SCHEMBL7794714 | 0.93 | HRH3 (0.53) | HRH3ADORA2AADORA1 | |
| SCHEMBL7786474 | 0.92 | HRH3 (0.55) | HRH3ADORA2AADORA1 | |
| SCHEMBL7786144 | 0.90 | LTA4H (0.51) | HRH3ADORA2AADORA1HTR3EHTR3B | |
| SCHEMBL7792420 | 0.90 | HRH3 (0.51) | HRH3ADORA2AADORA1HTR3EHTR3B | |
| SCHEMBL7786488 | 0.90 | ADORA2A (0.56) | ADORA2AADORA1 | |
| SCHEMBL7786054 | 0.89 | HRH3 (0.53) | HRH3ADORA2AADORA1HTR3EHTR3B | |
| SCHEMBL7786022 | 0.89 | HRH3 (0.53) | HRH3ADORA2AADORA1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |