Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524312 | 0.86 | TDP1 (0.58) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL23081633 | 0.83 | PDE7A (0.47) | TDP1SMN1; SMN2PDE7ATSHRGPR35 | |
| SCHEMBL27829945 | 0.81 | SMN1; SMN2 (0.46) | TDP1SMN1; SMN2PDE7ATSHRGPR35 | |
| SCHEMBL9872830 | 0.80 | MEN1 (0.50) | TDP1SMN1; SMN2PDE7ATSHRGPR35 | |
| SCHEMBL4151648 | 0.79 | TSHR (0.60) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL4725194 | 0.78 | TDP1 (0.48) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL4725240 | 0.78 | TDP1 (0.48) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL102957 | 0.78 | MAPT (0.49) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL29483006 | 0.78 | TDP1 (0.48) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 | |
| SCHEMBL28035882 | 0.78 | TDP1 (0.48) | TDP1SMN1; SMN2TSHRGPR35HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023092175-A1 | NOVEL P2X7 RECEPTOR ANTAGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023092175-A1 | NOVEL P2X7 RECEPTOR ANTAGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2023-06-01 | — | — | WO | disclosed |
| WO-2012068211-A1 | TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |
| US-7642277-B2 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| US-6251903-B1 | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist | COCENSYS, INC. | 2001-06-26 | — | — | US | disclosed |