Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524312 | 0.86 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL4151648 | 0.79 | TSHR (0.60) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL4725194 | 0.78 | TDP1 (0.48) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL8051898 | 0.78 | GPR35 (0.56) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL4725240 | 0.78 | TDP1 (0.48) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7786752 | 0.78 | TDP1 (0.48) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL102957 | 0.78 | MAPT (0.49) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL29483006 | 0.78 | TDP1 (0.48) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL27929047 | 0.76 | HCAR3 (0.42) | TDP1SMN1; SMN2GPR35ALDH1A1L3MBTL1 | |
| SCHEMBL26908112 | 0.75 | ERN1 (0.57) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324379-B | Benzimidazole derivatives as bromodomain inhibitors | 吉利德科学公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105324379-A | Benzimidazole derivatives as bromodomain inhibitors | GILEAD SCIENCES INC | 2016-02-10 | — | — | CN | disclosed |
| CN-105102453-A | Benzimidazolone derivatives as bromodomain inhibitors | GILEAD SCIENCES INC | 2015-11-25 | — | — | CN | disclosed |