SCHEMBL7786754

SCHEMBL7786754

COc1ccc2c(c1)/C(=C\C#N)C(c1ccccc1)C2

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
CYP19A1 P11511 3/20 0.43
ACHE P22303 1/20 0.41
ABCB1 P08183 1/20 0.41
AR P10275 1/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
MAOB P27338 3/20 0.38
METAP1 P53582 1/20 0.38
LMNA P02545 1/20 0.38
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE4D Q08499 1/20 0.37
MAP2K3 P46734 1/20 0.36
PTPN1 P18031 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7786757 1.00 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CYP19A1ACHE
SCHEMBL7786750 1.00 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CYP19A1ACHE
SCHEMBL7784456 0.81 CYP19A1 (0.43) CYP19A1ACHEMETAP1KDM4E
SCHEMBL7784454 0.81 CYP19A1 (0.43) CYP19A1ACHEMETAP1KDM4E
SCHEMBL7784452 0.81 CYP19A1 (0.43) CYP19A1ACHEMETAP1KDM4E
SCHEMBL7788139 0.80 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CYP19A1ACHE
SCHEMBL7788138 0.80 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CYP19A1ACHE
SCHEMBL4358495 0.76 ACHE (0.61) SLC6A2SLC6A4SLC6A3CYP19A1ACHE
SCHEMBL6590555 0.69 CYP11B1 (0.42) SLC6A2SLC6A4SLC6A3ACHELMNA
SCHEMBL6590559 0.69 CYP11B1 (0.42) SLC6A2SLC6A4SLC6A3ACHELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0848699-B1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-10-24 EP disclosed
US-6235789-B1 GLANDULAR DISORDERS; SLEEP DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0781271-B1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2000-06-07 EP disclosed
US-5922771-A MELATONIN RECEPTOR AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-13 US disclosed
EP-0848699-A1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-06-24 EP disclosed
EP-0781271-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-02 EP disclosed
WO-1997005098-A1 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-02-13 WO disclosed
WO-1996008466-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-03-21 WO disclosed