Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 12/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787711 | 1.00 | CXCR2 (0.41) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| SCHEMBL7789354 | 0.93 | MAPKAPK2 (0.45) | CXCR2MAPKAPK2AURKBROCK1PDGFRA | |
| SCHEMBL7785092 | 0.93 | MAPKAPK2 (0.45) | CXCR2MAPKAPK2AURKBROCK1PDGFRA | |
| SCHEMBL7801400 | 0.90 | S1PR3 (0.38) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| SCHEMBL7784941 | 0.90 | S1PR3 (0.38) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| SCHEMBL7787803 | 0.90 | MAPKAPK2 (0.40) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| SCHEMBL7780626 | 0.90 | S1PR3 (0.38) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| SCHEMBL7785292 | 0.89 | MAPKAPK2 (0.45) | MAPKAPK2AURKBROCK1PDGFRAMAPK1 | |
| Hydrochloric Acid SCHEMBL7795463 | 0.89 | S1PR3 (0.38) | CXCR2MAPKAPK2S1PR3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7801920 | 0.89 | S1PR3 (0.38) | CXCR2MAPKAPK2S1PR3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |