Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.53 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.39 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 6/20 | 0.37 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7784520 | 1.00 | DNM1 (0.53) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL6829877 | 0.98 | DNM1 (0.52) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL7785360 | 0.98 | DNM1 (0.52) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL7785321 | 0.98 | DNM1 (0.52) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| Hydrochloric Acid SCHEMBL29101687 | 0.97 | DNM1 (0.53) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL4085872 | 0.89 | TSHR (0.46) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL375827 | 0.89 | TSHR (0.46) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL372792 | 0.89 | TSHR (0.46) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL372624 | 0.89 | TSHR (0.46) | DNM1ZDHHC20ZDHHC2TSHRCA12 | |
| SCHEMBL431375 | 0.89 | TSHR (0.46) | DNM1ZDHHC20ZDHHC2TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948548-B1 | ANTIMICROBIAL POLYMERS COMPRISING QUATERNARY AMMONIUM GROUPS, THEIR USE FOR MAKING A MATERIAL WITH ANTIMICROBIAL PROPERTIES AND METHODS FOR PREPARING THEM | CATALYSE (FR) | 2001-11-14 | — | — | EP | claimed |
| US-6251967-B1 | SALT FORMING; THEN POLYMERIZATION | CATALYSE (SARL) LIMITED COMPANY (FR) | 2001-06-26 | — | — | US | disclosed |