Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 15/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7789781 | 0.99 | ESR1 (0.46) | ESR1ESR2MRGPRX4GRM2MEN1 | |
| SCHEMBL7789831 | 0.90 | GRM2 (0.53) | ESR1ESR2MRGPRX4GRM2MEN1 | |
| SCHEMBL7782033 | 0.85 | ESR2 (0.47) | ESR1ESR2MRGPRX4GRM2MEN1 | |
| SCHEMBL7786874 | 0.83 | ESR2 (0.46) | ESR1ESR2GRM2HPGD | |
| SCHEMBL1885756 | 0.83 | ESR2 (0.49) | ESR1ESR2GRM2MEN1KMT2A | |
| SCHEMBL7782054 | 0.83 | ESR2 (0.49) | ESR1ESR2GRM2MEN1KMT2A | |
| SCHEMBL6572282 | 0.82 | MEN1 (0.51) | ESR1ESR2GRM2MEN1TP53 | |
| SCHEMBL10738974 | 0.81 | MEN1 (0.50) | ESR1ESR2GRM2MEN1TP53 | |
| Potassium SCHEMBL10738982 | 0.81 | MEN1 (0.50) | ESR1ESR2GRM2MEN1TP53 | |
| SCHEMBL1892357 | 0.81 | ESR2 (0.48) | ESR1ESR2GRM2MEN1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251898-B1 | Medical use of fluorenone derivatives for treating and preventing brain and spinal injury | QUESTCOR PHARMACEUTICALS, INC. | 2001-06-26 | — | — | US | disclosed |
| WO-2001014334-A1 | FLUORENONE COMPOUNDS WITH MODIFIED 7-POSITION SUBSTITUENTS FOR TREATING AND PREVENTING BRAIN AND SPINAL INJURY | QUESTCOR PHARMACEUTICALS, INC. (US) | 2001-03-01 | — | — | WO | disclosed |