Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1174479 | 0.77 | HDAC1 (0.48) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7797525 | 0.69 | NAMPT (0.50) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL1264115 | 0.68 | HDAC6 (0.60) | HDAC1HDAC6HDAC3HDAC10HDAC8 | |
| SCHEMBL12869052 | 0.67 | HDAC6 (0.60) | HDAC6PRMT5WDR77NPC1KMT2A | |
| SCHEMBL21004729 | 0.66 | L3MBTL1 (0.57) | HSD11B1EP300CARM1ALDH1A1TSHR | |
| SCHEMBL1175271 | 0.65 | HDAC6 (0.64) | HDAC6HDAC8PRMT5WDR77NPC1 | |
| SCHEMBL3183338 | 0.64 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC2 | |
| SCHEMBL6490372 | 0.64 | HDAC1 (0.58) | HDAC1HDAC8NPC1KMT2AHSD11B1 | |
| SCHEMBL19339309 | 0.64 | NAMPT (0.60) | HDAC1NPC1KMT2AHSD11B1RAB9A | |
| SCHEMBL1174108 | 0.64 | HDAC6 (0.48) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151317-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |