Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.54 |
| ▸ | XIAP | P98170 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | DRD3 | P35462 | 5/20 | 0.33 |
| ▸ | F7 | P08709 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791541 | 0.94 | GHSR (0.53) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL7795636 | 0.94 | GHSR (0.54) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL7796066 | 0.93 | GHSR (0.57) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL7791686 | 0.93 | GHSR (0.53) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL8329860 | 0.91 | GHSR (0.66) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL7791823 | 0.91 | GHSR (0.46) | GHSRXIAPAGTR1HDAC3HDAC4 | |
| SCHEMBL7792151 | 0.90 | GHSR (0.55) | GHSRXIAPAGTR1DRD2DRD4 | |
| SCHEMBL7795546 | 0.90 | GHSR (0.61) | GHSRXIAPAGTR1DRD2DRD4 | |
| SCHEMBL7791742 | 0.89 | GHSR (0.54) | GHSRXIAPAGTR1DRD2DRD4 | |
| SCHEMBL7785956 | 0.89 | GHSR (0.56) | GHSRXIAPAGTR1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | claimed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |