Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.55 |
| ▸ | F7 | P08709 | 8/20 | 0.39 |
| ▸ | F3 | P13726 | 8/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 3/20 | 0.35 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791676 | 0.94 | GHSR (0.54) | GHSRF7F3XIAPF2 | |
| SCHEMBL7795553 | 0.94 | GHSR (0.53) | GHSRF7F3XIAPF2 | |
| SCHEMBL7795578 | 0.92 | GHSR (0.47) | GHSRF7F3XIAPF2 | |
| SCHEMBL7791998 | 0.92 | GHSR (0.57) | GHSRF7F3XIAPF2 | |
| SCHEMBL7795533 | 0.92 | GHSR (0.54) | GHSRF7F3XIAPF2 | |
| SCHEMBL7791798 | 0.91 | GHSR (0.67) | GHSRF7F3XIAPF2 | |
| SCHEMBL7792504 | 0.90 | GHSR (0.60) | GHSRF7F3XIAPF2 | |
| SCHEMBL7785956 | 0.89 | GHSR (0.56) | GHSRF7F3XIAPF2 | |
| SCHEMBL7791835 | 0.89 | GHSR (0.53) | GHSRF7F3XIAPMAPT | |
| SCHEMBL7785920 | 0.89 | GHSR (0.53) | GHSRF7F3XIAPF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | claimed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |