Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792655 | 0.97 | HTR2A (0.40) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7792631 | 0.95 | HTR2A (0.39) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7792711 | 0.92 | HTR2A (0.38) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7792340 | 0.91 | KCNA3 (0.37) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7792026 | 0.91 | HTR2A (0.37) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7795914 | 0.91 | TTR (0.43) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7792664 | 0.90 | HTR2A (0.36) | HTR2AHTR2CHTR2BKCNA3TTR | |
| SCHEMBL7795746 | 0.90 | SLC6A2 (0.37) | HTR2AHTR2CHTR2BKCNA3CHRNB4 | |
| SCHEMBL7786129 | 0.88 | KCNA3 (0.36) | HTR2AHTR2CHTR2BKCNA3ELANE | |
| SCHEMBL7795846 | 0.88 | HTR2A (0.36) | HTR2AHTR2CHTR2BKCNA3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |