Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792180 | 0.97 | KDM4E (0.48) | KDM4EALDH1A1HTTMAPK14BRD4 | |
| SCHEMBL7792176 | 0.97 | KDM4E (0.50) | KDM4EALDH1A1HTTMAPK14BRD4 | |
| SCHEMBL7786153 | 0.97 | KDM4E (0.47) | KDM4EALDH1A1HTTMAPK14BRD4 | |
| SCHEMBL7796357 | 0.97 | KDM4E (0.47) | KDM4EALDH1A1HTTMAPK14BRD4 | |
| SCHEMBL27495974 | 0.95 | KDM4E (0.45) | KDM4EALDH1A1HTTBRD4ADORA3 | |
| SCHEMBL7792104 | 0.95 | KDM4E (0.50) | KDM4EALDH1A1HTTMAPK14BRD4 | |
| SCHEMBL7786514 | 0.93 | TSHR (0.46) | KDM4EALDH1A1MAPK14TSHR | |
| Hydrochloric Acid SCHEMBL7792093 | 0.92 | ALDH1A1 (0.45) | KDM4EALDH1A1TSHR | |
| SCHEMBL7796433 | 0.92 | ALDH1A1 (0.55) | KDM4EALDH1A1HTTTSHR | |
| SCHEMBL7796393 | 0.92 | ALDH1A1 (0.52) | KDM4EALDH1A1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |