Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | RARG | P13631 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278077 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7792844 | 0.85 | DHODH (0.44) | PDE4APDE4BPDE4CPDE4DTRPV6 | |
| SCHEMBL7793501 | 0.83 | PRMT5 (0.46) | PDE4APDE4BPDE4CPDE4DALOX5AP | |
| SCHEMBL7793505 | 0.83 | CHEK2 (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7792898 | 0.81 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7792893 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7786900 | 0.77 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7786898 | 0.77 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7786844 | 0.76 | CHEK2 (0.49) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7786839 | 0.76 | PRMT5 (0.44) | PDE4APDE4BPDE4CPDE4DPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643701-B1 | BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF | CT INTERNAT DE RECH S BR DERMA (FR) | 2001-12-05 | — | — | EP | disclosed |
| US-5446059-A | Treating or preventing inflammatory or immunoallergic conditions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1995-08-29 | — | — | US | disclosed |