SCHEMBL7793501

SCHEMBL7793501

c1ccc(COc2ccc3[nH]c(-c4ccc(OCc5ccccc5)c(C56CC7CC(CC(C7)C5)C6)c4)nc3c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 16/20 0.46
CHEK2 O96017 1/20 0.43
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
ALOX5AP P20292 1/20 0.42
PTGES O14684 1/20 0.41
ALOX5 P09917 1/20 0.41
LTC4S Q16873 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7786898 0.94 PDE4A (0.47) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7792893 0.94 PDE4A (0.47) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7793505 0.93 CHEK2 (0.49) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7786839 0.93 PRMT5 (0.44) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL9278077 0.91 PDE4A (0.47) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7786900 0.86 PDE4A (0.53) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7792898 0.86 PDE4A (0.53) CHEK2PDE4APDE4BPDE4CPDE4D
SCHEMBL7786844 0.85 CHEK2 (0.49) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7786840 0.85 PDE4A (0.42) PRMT5CHEK2PDE4APDE4BPDE4C
SCHEMBL7792849 0.83 PDE4A (0.40) PRMT5PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643701-B1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CT INTERNAT DE RECH S BR DERMA (FR) 2001-12-05 EP claimed
US-5446059-A Treating or preventing inflammatory or immunoallergic conditions CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1995-08-29 US claimed
EP-0643701-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) 1995-03-22 EP claimed
WO-1992021663-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1992-12-10 WO claimed
EP-0643701-B1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CT INTERNAT DE RECH S BR DERMA (FR) 2001-12-05 EP disclosed
US-5446059-A Treating or preventing inflammatory or immunoallergic conditions CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1995-08-29 US disclosed
EP-0643701-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) 1995-03-22 EP disclosed
WO-1992021663-A1 BENZIMIDAZOLE-DERIVED COMPOUNDS, METHOD FOR PREPARING SAME, AND THERAPEUTICAL AND COSMETIC USES THEREOF CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1992-12-10 WO disclosed