Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 13/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871569 | 1.00 | GRIA2 (0.68) | GRIA2KCNH2GRIA4P2RX3LTA4H | |
| SCHEMBL1871574 | 1.00 | GRIA2 (0.68) | GRIA2KCNH2GRIA4P2RX3LTA4H | |
| SCHEMBL1871567 | 1.00 | GRIA2 (0.68) | GRIA2KCNH2GRIA4P2RX3LTA4H | |
| SCHEMBL1870115 | 0.85 | GRIA2 (0.49) | GRIA2KCNH2 | |
| SCHEMBL1870118 | 0.85 | GRIA2 (0.49) | GRIA2KCNH2 | |
| SCHEMBL1870116 | 0.85 | GRIA2 (0.49) | GRIA2KCNH2 | |
| SCHEMBL1872949 | 0.85 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1875180 | 0.85 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1875181 | 0.85 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL15936309 | 0.85 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445883-B1 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2010150192-A1 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 2010-12-29 | — | — | WO | disclosed |