⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154201 | 0.86 | KDM5A (0.33) | — | |
| SCHEMBL3271994 | 0.78 | KMT2A (0.40) | — | |
| SCHEMBL424385 | 0.77 | — | — | |
| SCHEMBL6199541 | 0.77 | S1PR2 (0.46) | — | |
| SCHEMBL2474282 | 0.75 | — | — | |
| SCHEMBL5542148 | 0.71 | S1PR2 (0.36) | — | |
| SCHEMBL15618888 | 0.71 | CHRNB2 (0.39) | — | |
| SCHEMBL4184981 | 0.70 | KDM4E (0.37) | — | |
| SCHEMBL96919 | 0.69 | — | — | |
| SCHEMBL5542805 | 0.69 | S1PR2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010001101-A1 | Phenanthroline derivatives | ZENECA LIMITED | 2001-05-10 | — | — | US | disclosed |
| EP-1027351-A1 | PHENANTHROLINE DERIVATIVES | FIBROGEN, INC. (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5916898-A | ANTIFIBROPROLIFERTIVE, ENZYME INHIBITORS OF PYROLYL 4-HYDROXYLASE, ANTIARTHRITIC AGENTS | ZENECA LIMITED (GB) | 1999-06-29 | — | — | US | disclosed |
| WO-1999021860-A1 | PHENANTHROLINE DERIVATIVES | FIBROGEN, INC. (US) | 1999-05-06 | — | — | WO | disclosed |