Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PAM | P19021 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6069090 | 0.98 | DGKA (0.50) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL4446360 | 0.86 | DGKA (0.53) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL3918186 | 0.86 | DGKA (0.53) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL2898744 | 0.86 | DGKA (0.53) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL3366257 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL5227396 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL7154415 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL4621082 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL152597 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT | |
| SCHEMBL15527970 | 0.85 | DGKA (0.67) | DGKALMNAPAMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947503-B1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | claimed |
| EP-0947503-A1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | claimed |
| EP-0947503-B1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | disclosed |
| EP-0947503-A1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | disclosed |