SCHEMBL7793751

SCHEMBL7793751

COc1ccc(-c2ccc(-c3ccc(OC(=O)O)cc3)cc2-c2ccc3c(c2)C(C)(C)CCC3(C)C)cc1

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
RARG P13631 18/20 0.58
RARB P10826 13/20 0.58
RARA P10276 11/20 0.58
RXRA P19793 3/20 0.53
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7792837 0.92 RARB (0.60) RARGRARBRARARXRA
SCHEMBL7794287 0.92 RARB (0.60) RARGRARBRARARXRA
SCHEMBL7793763 0.91 RARG (0.54) RARGRARBRARARXRA
SCHEMBL7792842 0.91 RARG (0.56) RARGRARBRARARXRA
SCHEMBL7784309 0.89 RARB (0.60) RARGRARBRARARXRA
SCHEMBL5846039 0.88 RARG (0.75) RARGRARBRARARXRA
SCHEMBL7792851 0.88 RARG (0.55) RARGRARBRARARXRA
SCHEMBL2945902 0.85 RARB (0.54) RARGRARBRARARXRA
SCHEMBL7790165 0.84 RARG (0.55) RARGRARBRARARXRA
SCHEMBL7793758 0.84 RARG (0.57) RARGRARBRARARXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0952974-B1 BIPHENYL DERIVATIVES SUBSTITUTED BY AN AROMATIC OR HETEROAROMATIC RADICAL AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME GALDERMA RES & DEV (FR) 2001-11-21 EP claimed