⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12564801 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL16876451 | 0.80 | — | — | |
| SCHEMBL4578719 | 0.79 | — | — | |
| SCHEMBL1098287 | 0.77 | — | — | |
| SCHEMBL87711 | 0.77 | — | — | |
| SCHEMBL3954454 | 0.77 | — | — | |
| SCHEMBL2281276 | 0.77 | — | — | |
| SCHEMBL7356952 | 0.77 | — | — | |
| SCHEMBL523805 | 0.77 | — | — | |
| SCHEMBL523957 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059185-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2025-02-20 | — | — | US | disclosed |
| EP-4448522-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2024-10-23 | — | — | EP | disclosed |
| CN-118488953-A | Bicyclic heterocyclic compounds useful as monoacylglycerol lipase inhibitors | 豪夫迈·罗氏有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-117916242-A | SHP2 inhibitors and uses thereof | 治纳辅医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023110958-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-06-22 | — | — | WO | disclosed |
| EP-0623119-B1 | NOVEL 3-HALO-5-HALOMETHYL-2-OXAZOLIDINONES AND THEIR USE AS MICROBICIDES | BUCKMAN LABOR INC (US) | 2001-11-28 | — | — | EP | disclosed |
| EP-0623119-A1 | NOVEL 3-HALO-5-HALOMETHYL-2-OXAZOLIDINONES AND THEIR USE AS MICROBICIDES | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 1994-11-09 | — | — | EP | disclosed |
| CN-1082545-A | Imidazopyridine | MERCK PATENT GMBH (DE) | 1994-02-23 | — | — | CN | disclosed |
| WO-1993013081-A1 | NOVEL 3-HALO-5-HALOMETHYL-2-OXAZOLIDINONES AND THEIR USE AS MICROBICIDES | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5162354-A | For controlling growth of microorganisms in aqueous system or surface | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0300272-B1 | OXAZOLIDINONES | MERCK PATENT GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |