SCHEMBL7793973

SCHEMBL7793973

COC(=O)c1ccc(-c2ncc(-c3ccc(O)cc3)cn2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.65
CA2 P00918 5/20 0.65
CA12 O43570 2/20 0.65
CA9 Q16790 2/20 0.65
CA14 Q9ULX7 2/20 0.65
MEN1 O00255 2/20 0.65
KMT2A Q03164 2/20 0.65
NPC1 O15118 1/20 0.65
RAB9A P51151 1/20 0.65
CA7 P43166 1/20 0.65
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
GAA P10253 2/20 0.50
KDM4E B2RXH2 3/20 0.49
MAPK1 P28482 2/20 0.47
EGFR P00533 1/20 0.47
ERN1 O75460 1/20 0.47
SGK1 O00141 1/20 0.46
CAMKK2 Q96RR4 1/20 0.46
HSD17B1 P14061 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7795432 1.00 CA1 (0.65) CA1CA2CA12CA9CA14
SCHEMBL8365053 0.86 CA1 (0.87) CA1CA2CA12CA9CA14
SCHEMBL4668655 0.86 CA1 (0.87) CA1CA2CA12CA9CA14
SCHEMBL21346781 0.81 TDP1 (0.60) CA1CA2CA12CA9CA14
SCHEMBL15994611 0.81 TDP1 (0.55) CA1CA2CA12CA9CA14
SCHEMBL5586458 0.80 NPC1 (1.00) MEN1KMT2ANPC1RAB9AALDH1A1
Methylparaben SCHEMBL321534 0.80 CA1 (1.00) CA1CA2CA12CA9CA14
Methylparaben SCHEMBL4440 0.80 CA1 (1.00) CA1CA2CA12CA9CA14
SCHEMBL2943965 0.80 CA1 (0.53) CA1CA2CA12CA9CA14
SCHEMBL7791042 0.80 ERN1 (0.52) CA1CA2CA12CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821050-B1 Optically active compound and antiferroelectric liquid crystal composition containing the same SEMICONDUCTOR ENERGY LAB (JP) 2001-11-28 EP disclosed
US-5820782-A LOW THRESHOLD VOLTAGE AND LOW VISCOSITY; PYRIMIDINE-BASED COMPOUND TAKASAGO INTERNATIONAL CORPORATION (JP) 1998-10-13 US disclosed
EP-0821050-A1 Optically active compound and antiferroelectric liquid crystal composition containing the same Takasago International Corporation (JP) 1998-01-28 EP disclosed