Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169760 | 1.00 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL24016961 | 1.00 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2478210 | 0.98 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL30514621 | 0.94 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL7794525 | 0.93 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL171236 | 0.89 | POLB (0.47) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL11526941 | 0.89 | MAPT (0.61) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL3400048 | 0.89 | MAPT (0.61) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL78145 | 0.89 | MAPT (0.61) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL11526739 | 0.86 | MAPT (0.63) | RAB9ANPC1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |