⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22661435 | 0.79 | MCL1 (0.44) | — | |
| SCHEMBL1750112 | 0.77 | — | — | |
| SCHEMBL6331416 | 0.74 | — | — | |
| SCHEMBL4178448 | 0.74 | — | — | |
| SCHEMBL8439782 | 0.72 | — | — | |
| SCHEMBL4165282 | 0.70 | MCL1 (0.38) | — | |
| SCHEMBL8950826 | 0.70 | — | — | |
| SCHEMBL11754508 | 0.70 | — | — | |
| SCHEMBL8950812 | 0.70 | — | — | |
| SCHEMBL6331826 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668137-A | N-heterocyclic sulfonamides having endothelin receptor activity | ZENECA LTD. (GB) | 1997-09-16 | — | — | US | claimed |
| EP-0749964-A1 | N-Heterocyclyl biphenyl sulfonamides | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | claimed |
| EP-0749964-B1 | N-Heterocyclyl biphenyl sulfonamides | ASTRAZENECA AB (SE) | 2001-10-04 | — | — | EP | disclosed |
| US-5668137-A | N-heterocyclic sulfonamides having endothelin receptor activity | ZENECA LTD. (GB) | 1997-09-16 | — | — | US | disclosed |
| EP-0749964-A1 | N-Heterocyclyl biphenyl sulfonamides | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |