Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.40 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669791 | 0.86 | MAPT (0.39) | RAB9ASMN1; SMN2ALDH1A1HASPINKDM4E | |
| SCHEMBL14280046 | 0.84 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL5262113 | 0.79 | MEN1 (0.39) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL7794896 | 0.78 | HASPIN (0.46) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL26039915 | 0.70 | KDM6B (0.65) | SMN1; SMN2ALDH1A1KDM6BKDM4AKDM4D | |
| SCHEMBL22557893 | 0.69 | KDM6B (0.43) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL7788353 | 0.69 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL1444090 | 0.67 | MEN1 (0.46) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL19243087 | 0.66 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL3955881 | 0.66 | XDH (0.43) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404695-B2 | Pyrimidinyl pyridone inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404695-B2 | Pyrimidinyl pyridone inhibitors of JNK | ROCHE PALO ALTO LLC (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2010046273-A2 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-29 | — | — | WO | disclosed |
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | ROCHE PALO ALTO LLC | 2010-04-22 | — | — | US | disclosed |
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | ROCHE PALO ALTO LLC | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099691-A1 | PYRIMIDINYL PYRIDONE INHIBITORS OF JNK | MAP3K20, MAP3K6, MAP3K1 | NPC1 3733/4885RAB9A 2501/4885SMN1; SMN2 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.