SCHEMBL7795732

SCHEMBL7795732

CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CSc3cc(OC)ccc32)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 4/20 0.65
XIAP P98170 3/20 0.40
MCHR1 Q99705 2/20 0.37
KCNA5 P22460 1/20 0.36
KCNH2 Q12809 1/20 0.36
CHRM5 P08912 1/20 0.36
AGTR1 P30556 1/20 0.35
F7 P08709 2/20 0.35
F3 P13726 2/20 0.35
F2 P00734 1/20 0.35
MAPT P10636 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7795592 0.94 GHSR (0.66) GHSRXIAPMCHR1KCNA5KCNH2
SCHEMBL7791716 0.93 GHSR (0.66) GHSRXIAPMCHR1KCNA5KCNH2
SCHEMBL7794398 0.93 GHSR (0.55) GHSRXIAPKCNA5KCNH2CHRM5
SCHEMBL7791658 0.92 GHSR (0.56) GHSRXIAPMCHR1KCNA5KCNH2
SCHEMBL7786077 0.91 GHSR (0.53) GHSRXIAPMCHR1CHRM5AGTR1
SCHEMBL7794384 0.90 GHSR (0.67) GHSRXIAPMCHR1KCNA5KCNH2
SCHEMBL7792002 0.90 GHSR (0.75) GHSRXIAPAGTR1F7F3
SCHEMBL7785745 0.90 GHSR (0.52) GHSRXIAPMCHR1CHRM5AGTR1
SCHEMBL8333260 0.89 GHSR (0.66) GHSRXIAPAGTR1F7F3
SCHEMBL7794697 0.89 GHSR (0.65) GHSRXIAPMCHR1AGTR1F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US claimed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO claimed
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed