Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.77 |
| ▸ | XIAP | P98170 | 6/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 3/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330883 | 0.92 | GHSR (0.83) | GHSRXIAPAGTR1NPY1RACE | |
| SCHEMBL7794392 | 0.91 | GHSR (0.64) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL7794388 | 0.91 | GHSR (0.64) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL8328852 | 0.90 | GHSR (0.63) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL7794445 | 0.90 | GHSR (0.62) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL8329866 | 0.89 | GHSR (0.88) | GHSRXIAPAGTR1PTGER1PTGER3 | |
| SCHEMBL8326513 | 0.89 | GHSR (0.66) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL8331766 | 0.89 | GHSR (0.63) | GHSRXIAPAGTR1PTGER1PTGER4 | |
| SCHEMBL7791986 | 0.89 | GHSR (0.85) | GHSRXIAPAGTR1NPY1RACE | |
| SCHEMBL8331781 | 0.88 | GHSR (0.86) | GHSRXIAPAGTR1PTGER1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |