Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | GHSR | Q92847 | 4/20 | 0.55 |
| ▸ | XIAP | P98170 | 7/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795943 | 1.00 | NPY1R (0.57) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL9024881 | 0.92 | GHSR (0.55) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL9025278 | 0.88 | SCN9A (0.56) | NPY1RGHSRXIAPSCN9A | |
| SCHEMBL9023535 | 0.86 | GHSR (0.70) | NPY1RGHSRXIAPAGTR1 | |
| SCHEMBL7795959 | 0.86 | GHSR (0.64) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL7795957 | 0.86 | GHSR (0.64) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL9024848 | 0.84 | GHSR (0.57) | NPY1RGHSRXIAPAGTR1 | |
| SCHEMBL7795524 | 0.84 | GHSR (0.68) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL7795526 | 0.84 | GHSR (0.68) | NPY1RGHSRXIAPAGTR1SCN9A | |
| SCHEMBL9024480 | 0.83 | GHSR (0.53) | NPY1RGHSRXIAPAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |