Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.55 |
| ▸ | PDE4A | P27815 | 9/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796238 | 1.00 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7409643 | 0.88 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7786662 | 0.88 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7786677 | 0.88 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6171292 | 0.80 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6175086 | 0.80 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6171289 | 0.80 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7318584 | 0.78 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8879699 | 0.78 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546469 | 0.78 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |