Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 8/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786367 | 0.93 | KCNA3 (0.50) | KCNA3AVPR2AVPR1AITGB3ITGA2B | |
| SCHEMBL7786542 | 0.89 | KCNA3 (0.44) | KCNA3NPY1R | |
| SCHEMBL7794712 | 0.86 | KCNA3 (0.47) | KCNA3ITGB3ITGA2BNPY1RTERT | |
| SCHEMBL7796210 | 0.85 | HTR2A (0.44) | KCNA3AVPR2AVPR1AHTR2AHTR2C | |
| SCHEMBL7792363 | 0.85 | HTR2A (0.47) | KCNA3AVPR2AVPR1AHTR2AHTR2C | |
| SCHEMBL7791763 | 0.85 | ELANE (0.44) | KCNA3AVPR2AVPR1AITGB3ITGA2B | |
| SCHEMBL7786436 | 0.84 | HTR2A (0.45) | KCNA3AVPR2AVPR1AHTR2AHTR2C | |
| SCHEMBL7792232 | 0.84 | MEN1 (0.42) | KCNA3AVPR2AVPR1AHTR2AHTR2C | |
| SCHEMBL7792607 | 0.84 | HTR2A (0.42) | KCNA3AVPR2AVPR1AHTR2AHTR2C | |
| SCHEMBL7794753 | 0.84 | HTR2A (0.41) | KCNA3AVPR2AVPR1AITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |