Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.79 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.66 |
| ▸ | PDE5A | O76074 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CA3 | P07451 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013938 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL213124 | 0.88 | PTGS2 (0.84) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL6341527 | 0.88 | PTGS2 (1.00) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL6340118 | 0.88 | PTGS2 (0.82) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL6349806 | 0.87 | PTGS2 (1.00) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL6464094 | 0.86 | PTGS2 (0.84) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL6463281 | 0.85 | PTGS2 (0.82) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL7798034 | 0.85 | PTGS2 (0.75) | PTGS2PTGS1PDPK1CYP2C9PTGES | |
| SCHEMBL7789625 | 0.84 | PTGS2 (0.80) | PTGS2PTGS1ABCB11 | |
| SCHEMBL6339234 | 0.84 | PTGS2 (0.76) | PTGS2PTGS1PDPK1CYP2C9PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2001-12-27 | — | — | US | disclosed |
| US-6045773-A | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0859642-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997014679-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1997-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885PTGS1 4/4885PDPK1 3876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.