Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618611 | 0.82 | CTSA (0.40) | SMN1; SMN2KMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL7798971 | 0.82 | CTSA (0.43) | SMN1; SMN2KMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL7799009 | 0.81 | CTSA (0.43) | SMN1; SMN2KMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL15173988 | 0.78 | CTSA (0.38) | SMN1; SMN2KMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL11606907 | 0.76 | TRPM8 (0.35) | SMN1; SMN2KMT2ACYP1A2TRPM8ALDH1A1 | |
| SCHEMBL17616528 | 0.75 | EPHX1 (0.42) | KDM4ECYP1A2NPSR1GRIN2DGRIN3B | |
| SCHEMBL17596091 | 0.75 | EPHX1 (0.42) | KDM4ECYP1A2NPSR1GRIN2DGRIN3B | |
| SCHEMBL17616529 | 0.75 | EPHX1 (0.42) | KDM4ECYP1A2NPSR1GRIN2DGRIN3B | |
| SCHEMBL14580272 | 0.74 | KMT2A (0.41) | SMN1; SMN2KMT2AGABBR2GABBR1 | |
| SCHEMBL16151353 | 0.73 | KMT2A (0.40) | SMN1; SMN2KMT2AKDM4EMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163222-A1 | PROCESS OF PREPARING 3S-3-AMINO-3-ARYL PROPIONIC ACID AND DERIVATIVES THEREOF | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056715-A1 | PROCESS OF PREPARING 3S-3-AMINO-3-ARYL PROPIONIC ACID AND DERIVATIVES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-09-28 | — | — | WO | disclosed |