SCHEMBL7797202

SCHEMBL7797202

O=c1cccc2[nH]c3ccc(O)cc3cc1-2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AURKA O14965 1/20 0.51
CDK1 P06493 1/20 0.51
KDR P35968 1/20 0.51
FLT3 P36888 8/20 0.47
PDGFRB P09619 3/20 0.47
KIT P10721 2/20 0.47
ABL1 P00519 1/20 0.47
BCR P11274 1/20 0.47
CLK1 P49759 1/20 0.47
DYRK1A Q13627 1/20 0.47
SMAD3 P84022 1/20 0.46
PDGFRA P16234 1/20 0.45
CA2 P00918 1/20 0.44
CDK5 Q00535 3/20 0.42
CDK5R1 Q15078 3/20 0.42
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
CASP6 P55212 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19290 0.80 KDR (0.61) AURKAKDRFLT3PDGFRBCA2
SCHEMBL4674979 0.77 KDR (0.57) AURKAKDRFLT3PDGFRBCA2
Acetic Acid SCHEMBL10322226 0.75 KDR (0.51) AURKAKDRFLT3PDGFRBPDGFRA
SCHEMBL11232109 0.74 KDR (0.50) AURKAKDRFLT3PDGFRBCA2
SCHEMBL27488931 0.74 KDR (0.77) AURKACDK1KDRFLT3PDGFRB
Phosphoric Acid SCHEMBL9660622 0.73 KDR (0.49) AURKAKDRFLT3PDGFRBCA2
SCHEMBL3019684 0.71 CDK5 (0.56) AURKACDK1KDRFLT3PDGFRB
SCHEMBL9270293 0.71 SMAD3 (0.50) CDK1KDRFLT3PDGFRBKIT
SCHEMBL19889776 0.70 CDK5 (0.51) AURKACDK1KDRFLT3PDGFRB
SCHEMBL27291636 0.70 CDK1 (0.53) AURKACDK1KDRFLT3PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303385-B2 TRANSPARENT SUPPORT MATERIAL, LAYER OF WATER-INSOLUBLE COPOLYMERS THAT ARE COMPOSED OF N,N-DIMETHYLACRYLAMIDE OR N,N-DIMETHYLMETHACRYLAMIDE, FLUOROPHORE WHICH IS COVALENTLY BONDED TO THE POLYMER NOVARTIS AG (CH) 2001-10-16 US disclosed
US-20010018217-A1 Acrylic amide copolymer crosslinked with diolefins; covalently bonded to pH sensitive fluorescent dyes; physiological solution, i.e. blood; ionic strength-independent BARNARD STEVEN MARK (US) 2001-08-30 US disclosed
US-6252024-B1 WATER INSOLUBLE COPOLYMER NOVARTIS AG (CH) 2001-06-26 US disclosed
EP-0862741-B1 OPTICAL SENSOR SYSTEM FOR THE DETERMINATION OF PH VALUES INDEPENDENTLY OF IONIC STRENGTH NOVARTIS AG (CH) 2001-04-25 EP disclosed
EP-0758361-B1 POLYMERISABLE COMPOSITION AND THE USE THEREOF NOVARTIS AG (CH) 2000-11-15 EP disclosed
US-5922612-A INDEPENDENT, REVERSIBLE FLUORESCENCE SPECTROMETRY OF SAMPLE USING TWO OPTICAL SENSORS COMPOSED OF A CARRIER EACH COATED WITH DIFFERENT WATER INSOLUBLE BUT HYDROPHILIC ADDITION POLYMER LOADED WITH THE SAME FLUORESCENT DYE NOVARTIS CORPORATION (US) 1999-07-13 US disclosed
EP-0758451-B1 OPTICAL SENSOR SYSTEM FOR DETERMINING pH VALUES AND IONIC STRENGTHS NOVARTIS AG (CH) 1999-01-20 EP disclosed
US-5852126-A Polymerisable composition and the use thereof NOVARTIS AG (CH) 1998-12-22 US disclosed
EP-0862741-A1 OPTICAL SENSOR SYSTEM FOR THE DETERMINATION OF PH VALUES INDEPENDENTLY OF IONIC STRENGTH Novartis AG (CH) 1998-09-09 EP disclosed
WO-1997015832-A1 OPTICAL SENSOR SYSTEM FOR THE DETERMINATION OF PH VALUES INDEPENDENTLY OF IONIC STRENGTH NOVARTIS AG (CH) 1997-05-01 WO disclosed
EP-0758361-A1 POLYMERISABLE COMPOSITON AND THE USE THEREOF Novartis AG (CH) 1997-02-19 EP disclosed
EP-0758451-A1 OPTICAL SENSOR SYSTEM FOR DETERMINING pH VALUES AND IONIC STRENGTHS Novartis AG (CH) 1997-02-19 EP disclosed
WO-1995030148-A1 OPTICAL SENSOR SYSTEM FOR DETERMINING pH VALUES AND IONIC STRENGTHS CIBA-GEIGY AG (CH) 1995-11-09 WO disclosed
WO-1995029959-A1 POLYMERISABLE COMPOSITON AND THE USE THEREOF CIBA-GEIGY AG (CH) 1995-11-09 WO disclosed