Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND1 | P24385 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008746 | 0.81 | KDR (0.68) | PDGFRBNPC1CDK5CDK5R1CHEK1 | |
| SCHEMBL29712353 | 0.81 | KDR (0.68) | PDGFRBNPC1CDK5CDK5R1CHEK1 | |
| SCHEMBL29206329 | 0.81 | CYP19A1 (0.61) | NPC1CDK5CDK5R1CHEK1PIM1 | |
| SCHEMBL10980382 | 0.81 | KMT2A (0.61) | FLT3NPC1CDK5CDK5R1CHEK1 | |
| SCHEMBL6168341 | 0.81 | DAO (0.57) | PDGFRBPDGFRANPC1MEN1KMT2A | |
| SCHEMBL30875870 | 0.81 | CYP19A1 (0.61) | NPC1CDK5CDK5R1CHEK1PIM1 | |
| SCHEMBL17505156 | 0.81 | NPC1 (0.51) | PDGFRBFLT3NPC1CDK5CDK5R1 | |
| SCHEMBL27488931 | 0.80 | KDR (0.77) | PDGFRBFLT3PDGFRACDK5CDK5R1 | |
| SCHEMBL7196311 | 0.77 | ALDH1A1 (0.70) | PDGFRBFLT3PDGFRANPC1PIM1 | |
| SCHEMBL6741892 | 0.76 | CYP19A1 (0.64) | SMAD3PDGFRBFLT3PDGFRANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995003300-A1 | HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1995-02-02 | — | — | WO | disclosed |