Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 8/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 8/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 8/20 | 1.00 |
| ▸ | ESR1 | P03372 | 9/20 | 0.88 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.88 |
| ▸ | MAPT | P10636 | 3/20 | 0.88 |
| ▸ | MEN1 | O00255 | 3/20 | 0.88 |
| ▸ | TP53 | P04637 | 3/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.88 |
| ▸ | PGR | P06401 | 2/20 | 0.88 |
| ▸ | ESRRG | P62508 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | HTR6 | P50406 | 2/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.88 |
| ▸ | EGFR | P00533 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151532 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL7797462 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL2827282 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767718 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767725 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767709 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL60433 | 0.94 | ESR1 (0.95) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL60434 | 0.94 | ESR1 (0.95) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL17262111 | 0.94 | ESR1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL17262082 | 0.94 | ESR1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226160-A9 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-07-11 | — | — | US | disclosed |
| CN-110291200-B | Agent ligand induction of transgene expression in mammalian cells | 西雅图儿童医院（DBA西雅图儿童研究所） | 2024-05-14 | — | — | CN | disclosed |
| US-20240131072-A1 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-04-25 | — | — | US | disclosed |
| EP-4341283-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A TRANSCRIPTION FACTOR AND A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-4291571-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2023-12-20 | — | — | EP | disclosed |
| CN-117177989-A | Activity-inducible fusion proteins with heat shock protein 90 binding domain | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 2023-12-05 | — | — | CN | disclosed |
| EP-3551197-B1 | CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS | SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) | 2023-11-22 | — | — | EP | disclosed |
| WO-2023187031-A1 | A SYSTEM FOR DRUG-INDUCIBLE EXPRESSION OF A POLYNUCLEOTIDE | Miltenyi Biotec B.V. & Co. KG (DE) | 2023-10-05 | — | — | WO | disclosed |
| US-20230242936-A1 | DUAL PROMOTER SYSTEMS | SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) | 2023-08-03 | — | — | US | disclosed |
| CN-108174604-B | Bispecific CAR T cells for solid tumor targeting | 西雅图儿童医院（DBA西雅图儿童研究所） | 2023-06-23 | — | — | CN | disclosed |
| WO-2018111763-A1 | CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2018-06-21 | — | — | WO | disclosed |
| EP-3331920-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017123548-A1 | TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-07-20 | — | — | WO | disclosed |
| US-20170152297-A1 | DRUG REGULATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2017-06-01 | — | — | US | disclosed |
| CN-106573969-A | Drug-related transgene expression | 西雅图儿童医院（DBA西雅图儿童研究所） | 2017-04-19 | — | — | CN | disclosed |
| WO-2017027291-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-02-16 | — | — | WO | disclosed |
| EP-3129399-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2017-02-15 | — | — | EP | disclosed |
| WO-2015157432-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2015-10-15 | — | — | WO | disclosed |
| US-20010047033-A1 | Composition for and method of preventing or treating breast cancer | PROTEIN TECHNOLOGIES INTERNATIONAL, INC. | 2001-11-29 | — | — | US | disclosed |
| US-6300367-B1 | Composition for and method of preventing or treating breast cancer | PROTEIN TECHNOLOGIES INTERNATIONAL, INC. | 2001-10-09 | — | — | US | disclosed |