Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 8/20 | 1.00 |
| ▸ | PDE1B | Q01064 | 8/20 | 1.00 |
| ▸ | PDE1C | Q14123 | 8/20 | 1.00 |
| ▸ | ESR1 | P03372 | 9/20 | 0.88 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.88 |
| ▸ | MAPT | P10636 | 3/20 | 0.88 |
| ▸ | MEN1 | O00255 | 3/20 | 0.88 |
| ▸ | TP53 | P04637 | 3/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.88 |
| ▸ | PGR | P06401 | 2/20 | 0.88 |
| ▸ | ESRRG | P62508 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | HTR6 | P50406 | 2/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.88 |
| ▸ | EGFR | P00533 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151532 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL7797461 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL2827282 | 1.00 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767718 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767725 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767709 | 0.94 | PDE1A (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL60433 | 0.94 | ESR1 (0.95) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL60434 | 0.94 | ESR1 (0.95) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL17262111 | 0.94 | ESR1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 | |
| Tamoxifen SCHEMBL17262082 | 0.94 | ESR1 (1.00) | PDE1APDE1BPDE1CESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010047033-A1 | Composition for and method of preventing or treating breast cancer | PROTEIN TECHNOLOGIES INTERNATIONAL, INC. | 2001-11-29 | — | — | US | disclosed |
| US-6300367-B1 | Composition for and method of preventing or treating breast cancer | PROTEIN TECHNOLOGIES INTERNATIONAL, INC. | 2001-10-09 | — | — | US | disclosed |
| EP-0260066-B1 | TAMOXIFEN DERIVATIVES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-05-09 | — | — | EP | disclosed |
| US-4839155-A | Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-06-13 | — | — | US | disclosed |