Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8021863 | 0.99 | KMO (0.34) | KMOHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7804915 | 0.89 | HTR2A (0.33) | HTR2AHTR2CHTR1DHTR1BCYP1A2 | |
| SCHEMBL7804929 | 0.77 | CYP19A1 (0.40) | KMOHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7256657 | 0.77 | KMO (0.40) | KMOHTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7253093 | 0.76 | LRRK2 (0.41) | LMNA | |
| Hydrochloric Acid SCHEMBL8031599 | 0.76 | CYP19A1 (0.39) | KMOHTR2AHTR2CHTR2BHTR1A | |
| Hydrochloric Acid SCHEMBL8035283 | 0.75 | HTR1D (0.32) | HTR1DHTR1BCYP1A2CYP2C9LMNA | |
| SCHEMBL7798149 | 0.71 | HTR1D (0.41) | KMOHTR2AHTR2CHTR2BHTR1A | |
| Hydrochloric Acid SCHEMBL8021866 | 0.70 | HTR1D (0.41) | KMOHTR2AHTR2CHTR2BHTR1A | |
| Hydrochloric Acid SCHEMBL8031631 | 0.69 | HTR1D (0.32) | HTR1DHTR1BCYP1A2CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | claimed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | claimed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | claimed |
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |