Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7798544 | 1.00 | LTA4H (0.46) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Phenylacetic Acid SCHEMBL7800120 | 0.97 | LTA4H (0.47) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Phenylacetic Acid SCHEMBL7800123 | 0.97 | LTA4H (0.47) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Lysine SCHEMBL7798424 | 0.96 | LTA4H (0.47) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Lysine SCHEMBL7798422 | 0.96 | LTA4H (0.47) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Lysine SCHEMBL7800220 | 0.96 | LTA4H (0.50) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Lysine SCHEMBL7800215 | 0.96 | LTA4H (0.50) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Phenylacetic Acid SCHEMBL7802505 | 0.93 | LTA4H (0.48) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Phenylacetic Acid SCHEMBL7802503 | 0.93 | LTA4H (0.48) | LTA4HPOLBTDP1ALDH1A1SLC1A3 | |
| Ornithine SCHEMBL7798491 | 0.93 | LTA4H (0.51) | LTA4HPOLBTDP1ALDH1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |