Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.59 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.59 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.59 |
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7333855 | 1.00 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Bromide SCHEMBL7333859 | 1.00 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7799046 | 0.99 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7799044 | 0.99 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7331021 | 0.93 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7331015 | 0.93 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7368787 | 0.93 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL7333900 | 0.93 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL7333905 | 0.93 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7368019 | 0.93 | DRD3 (0.55) | ADRA1DADRA1AADRA1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |