Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.46 |
| ▸ | DRD2 | P14416 | 10/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799143 | 1.00 | DRD3 (0.46) | DRD3DRD2FYNADRA1DADRA1A | |
| SCHEMBL7330888 | 0.89 | DRD2 (0.52) | DRD3DRD2FYNADRA1DADRA1A | |
| SCHEMBL7330886 | 0.89 | DRD2 (0.52) | DRD3DRD2FYNADRA1DADRA1A | |
| SCHEMBL7799078 | 0.87 | DRD3 (0.56) | DRD3DRD2FYN | |
| SCHEMBL7799075 | 0.87 | DRD3 (0.56) | DRD3DRD2FYN | |
| Formic Acid SCHEMBL7797225 | 0.87 | DRD2 (0.49) | DRD3DRD2FYNADRA1DADRA1A | |
| Formic Acid SCHEMBL7797231 | 0.87 | DRD2 (0.49) | DRD3DRD2FYNADRA1DADRA1A | |
| SCHEMBL7334491 | 0.86 | DRD2 (0.52) | DRD3DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL8884984 | 0.85 | FYN (0.36) | DRD3DRD2FYNDRD4HTR1A | |
| SCHEMBL7330855 | 0.85 | FYN (0.42) | DRD3DRD2FYNADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |