SCHEMBL7799197

SCHEMBL7799197

CCCCOC(=O)Nc1cccc([N+](=O)[O-])c1C

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
CYP2C19 P33261 3/20 0.57
CYP1A2 P05177 2/20 0.57
CYP2C9 P11712 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
POLB P06746 3/20 0.54
SMN1; SMN2 Q16637 4/20 0.54
LMNA P02545 2/20 0.53
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
GAA P10253 2/20 0.50
BLM P54132 1/20 0.50
NPC1 O15118 1/20 0.50
MAPK1 P28482 1/20 0.50
RAB9A P51151 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.49
TAS1R1 Q7RTX1 1/20 0.49
TAS1R2 Q8TE23 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21059235 0.88 KMT2A (0.61) ALDH1A1CYP2C19CYP1A2L3MBTL1SMN1; SMN2
SCHEMBL9463670 0.86 POLB (0.55) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1
SCHEMBL3386794 0.85 SMN1; SMN2 (0.65) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1
SCHEMBL21059249 0.85 KMT2A (0.60) ALDH1A1CYP2C19CYP1A2L3MBTL1SMN1; SMN2
SCHEMBL21059226 0.84 KMT2A (0.58) ALDH1A1CYP2C19CYP1A2L3MBTL1SMN1; SMN2
SCHEMBL7564366 0.81 SMN1; SMN2 (0.60) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1
SCHEMBL1956240 0.81 NLRP3 (0.66) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1
SCHEMBL21059154 0.80 KMT2A (0.67) ALDH1A1CYP2C19CYP1A2L3MBTL1SMN1; SMN2
SCHEMBL7420206 0.80 SMN1; SMN2 (0.59) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1
SCHEMBL31209988 0.79 SMN1; SMN2 (0.55) ALDH1A1CYP2C19CYP1A2CYP2C9L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163220-A1 TRICYCLIC INDOLE-2-CARBOXYLIC ACID COMPOUND USED AS NMDA RECEPTOR ANTAGONIST SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-12-19 EP disclosed
WO-2000056711-A1 TRICYCLIC INDOLE-2-CARBOXYLIC ACID COMPOUND USED AS NMDA RECEPTOR ANTAGONIST SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 2000-09-28 WO disclosed