Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132655 | 0.81 | HTT (0.79) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL14445319 | 0.81 | HTT (0.64) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL10955741 | 0.81 | HTT (0.64) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL28129565 | 0.79 | TGM2 (0.63) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL10970250 | 0.79 | HTT (0.63) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL7820797 | 0.79 | HTT (0.89) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL27860862 | 0.79 | HTT (0.69) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL14729295 | 0.79 | HTT (0.69) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL9316550 | 0.79 | HDAC3 (0.65) | HTTTGM2HDAC6HDAC3HDAC1 | |
| SCHEMBL18900912 | 0.78 | HTT (0.61) | HTTTGM2HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |