SCHEMBL7799745

SCHEMBL7799745

COc1ccc(Cl)c(NC=O)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.51
OR51E2 Q9H255 1/20 0.48
P2RX7 Q99572 1/20 0.43
HDAC1 Q13547 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
SRC P12931 4/20 0.42
ALDH1A1 P00352 3/20 0.41
NPSR1 Q6W5P4 2/20 0.41
HTT P42858 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
AKR1C3 P42330 1/20 0.40
AKR1C2 P52895 1/20 0.40
ABL1 P00519 1/20 0.40
BCR P11274 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758614 0.80 ALDH1A1 (0.56) OR51E2ALDH1A1NPSR1HTTLMNA
SCHEMBL1911389 0.80 OR51E2 (0.46) OR51E2P2RX7ALDH1A1NPSR1HTT
SCHEMBL30996639 0.79 ALDH1A1 (0.58) OR51E2ALDH1A1HTTCYP1A2CYP2C19
SCHEMBL1188765 0.79 OR51E2 (0.45) OR51E2ALDH1A1HTTLMNAPOLB
SCHEMBL9227792 0.77 TDP1 (0.53) TDP1P2RX7HDAC1HDAC8HDAC6
SCHEMBL15764263 0.77 TDP1 (0.53) TDP1P2RX7HDAC1HDAC8HDAC6
SCHEMBL2203559 0.76 ALDH1A1 (0.56) OR51E2ALDH1A1HTTCYP1A2LMNA
SCHEMBL5597294 0.76 GAA (0.53) OR51E2ALDH1A1HTTCYP1A2ERN1
SCHEMBL24575897 0.76 KMT2A (0.46) OR51E2ALDH1A1NPSR1HTTLMNA
SCHEMBL16438075 0.76 OR51E2 (0.43) OR51E2ALDH1A1NPSR1HTTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161499-A1 AZOXY DYES AND THEIR CU COMPLEXES BASF AKTIENGESELLSCHAFT (DE) 2001-12-12 EP disclosed
WO-2000055259-A1 AZOXY DYES AND THEIR CU COMPLEXES BASF AKTIENGESELLSCHAFT (DE) 2000-09-21 WO disclosed