Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.55 |
| ▸ | RARB | P10826 | 12/20 | 0.55 |
| ▸ | RARG | P13631 | 11/20 | 0.55 |
| ▸ | RARA | P10276 | 9/20 | 0.55 |
| ▸ | RXRB | P28702 | 8/20 | 0.55 |
| ▸ | RXRG | P48443 | 6/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517377 | 0.90 | RXRA (0.44) | RXRARARBRARGRARARXRB | |
| SCHEMBL7799795 | 0.85 | RARB (0.56) | RXRARARBRARGRARARXRB | |
| SCHEMBL12517137 | 0.83 | RARB (0.55) | RXRARARBRARGRARARXRB | |
| SCHEMBL12517113 | 0.81 | RXRA (0.48) | RXRARARBRARGRARARXRB | |
| SCHEMBL12517363 | 0.81 | RARB (0.52) | RXRARARBRARGRARARXRB | |
| SCHEMBL12517380 | 0.80 | RXRA (0.47) | RXRARARBRARGRARARXRB | |
| SCHEMBL1550094 | 0.80 | CYP3A4 (0.59) | RXRARARBRARGRARARXRB | |
| SCHEMBL3301372 | 0.79 | RARB (0.61) | RXRARARBRARGRARARXRB | |
| SCHEMBL12515953 | 0.79 | RARB (0.66) | RXRARARBRARGRARARXRB | |
| SCHEMBL12517022 | 0.77 | RXRA (0.52) | RXRARARBRARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882033-B1 | BENZOFURAN-ACRYLIC ACID DERIVATIVES AND THEIR USE AS MODULATORS OF RXRS OR RARS RECEPTORS | CT INTERNAT DE RECH S (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-6030952-A | AS HUMAN AND VETERINARY MEDICINE, PARTICULARLY IN THE TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGIC CONDITIONS, AND IN COSMETIC COMPOSITIONS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES GALDERMA (FR) | 2000-02-29 | — | — | US | disclosed |